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KMID : 0616120060370030136
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Korean Journal of Pharmacognosy
2006 Volume.37 No. 3 p.136 ~ p.142
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Analgesic Effect and Inhibition of Prostaglandin E 2 Acitivity and Pro-inflammatofy Cytokines Production by Ethyl Alcohol
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Kwon Soon-Yong
Lee Hwa-Sung
Lee Soon-Hyuck
Im Gun-Il
Kim Si-Na
Kim Hee-Seok
Hwang Sung-Wan
Hwang Sung-Yeoun
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Abstract
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New herbal formula (NHF) is the ethanol extract mixture of Puerariae radix, Artemisia capillaries and Perilla frutescens. We have investigated the effects on anti-inflammation by NHF and attempted acetic acid induced writhing to verify the analgesic effect. Macrophages and chondrocytes were obtained from mouse and rabbit. Inflammation was induced by interleukin-1, tumor necrosis factor-α, interferon-γ, and lipopolysaccaride. NHF showed strong inhibitory efficacy against cytokine-induced proteoglycal degradation, PGE2 production, NO production, and MMP-9 expression in rabbit articular chondrocyte. In the writhing test, NHF exhibited a dose-dependent inhibition of writhing. Futhermore, NHF increased the activity of SOD. NHF have anti-inflammatory and analgesic activities, and could be a good gerbal medicine candidate for curing of osteoarthritis.
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KEYWORD
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Anti-inflammation, Analgesic, PGE2, MMPs, osteoarthritis
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